Does modafinil cause Steven Johnson Syndrome?
Introduction: Stevens- Johnson Syndrome (SJS) is reported as a possible adverse effect for modafinil and armodafinil, yet no definitive case has been presented in the literature. A warning associating these drugs with SJS is primarily based on a rash that formed on one patient during modafinil clinical trials.
Which drug is most likely to cause Stevens-Johnson syndrome?
What drugs are most likely to cause Stevens-Johnson syndrome? Medications most likely to cause Stevens-Johnson syndrome include: Antibacterial sulfa drugs. Anti-epileptic drugs, including phenytoin (Dilantin®), carbamazepine (Tegretol®), lamotrigine (Lamictal®), and phenobarbital (Luminal®).
What does Steven Johnson Syndrome look like in the beginning?
Stevens-Johnson syndrome can start with flu-like symptoms, such as a high temperature, sore throat, cough and joint pain. A rash appears a few days later. It’s made up of circular patches that are darker in the middle and lighter around the outside.
Can modafinil cause skin rash?
Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.
Does modafinil affect your heart?
Modafinil substantially perturbs autonomic cardiovascular regulation by increase in heart rate and blood pressure. Autonomic changes of this magnitude encourage caution in use of modafinil in patients with cardiovascular disease.
What are the side effects of modafinil?
Modafinil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep.
How quickly does SJS develop?
Clinical Presentation. The typical clinical course of SJS begins within 8 weeks (usually 4 to 30 days) following the first exposure to the causative agent. Only in very rare cases where an inadvertent rechallenge occurs do symptoms appear within hours.
How quickly does Stevens-Johnson syndrome start?
One to three days before a rash develops, you may show early signs of Stevens-Johnson syndrome, including: Fever. A sore mouth and throat. Fatigue.
How long does SJS take to develop?
The typical clinical course of SJS begins within 8 weeks (usually 4 to 30 days) following the first exposure to the causative agent. Only in very rare cases where an inadvertent rechallenge occurs do symptoms appear within hours.
How do I know if I have Stevens-Johnson syndrome?
Unexplained widespread skin pain. A red or purple rash that spreads. Blisters on your skin and the mucous membranes of the mouth, nose, eyes and genitals. Shedding of skin within days after blisters form.
- A sore mouth and throat.
- Burning eyes.
What can you not mix with modafinil?
Notes for Consumers: You can take Modafinil with or without most foods. However, Grapefruit-juice and Grapefruit may increase the actions or side effects of Modafinil, which may cause headache, nausea and vomiting, nervousness, difficulty sleeping or other side effects.
What are the negative effects of modafinil?
Modafinil may cause some people to feel dizzy, drowsy, have trouble thinking or controlling movements, or trouble seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.
Who should not use modafinil?
You should not use modafinil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil). Modafinil can cause skin reactions that may be severe enough to need treatment in a hospital.
Can you survive Steven Johnson Syndrome?
About 10 percent of people with Stevens-Johnson syndrome die from the disease, while the condition is fatal in up to 50 percent of those with toxic epidermal necrolysis.
Can Steven Johnson syndrome be stopped?
If the underlying cause of Stevens-Johnson syndrome can be eliminated and the skin reaction stopped, new skin may begin to grow within several days. In severe cases, full recovery may take several months.
How fast does Steven Johnson syndrome develop?
The drugs that precipitate Stevens-Johnson syndrome/toxic epidermal necrolysis tend to have long half-lives and are nearly always taken systemically. Stevens-Johnson syndrome/toxic epidermal necrolysis can develop within a few days to eight weeks after starting a new drug.
Is it okay to skip a day of modafinil?
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of modafinil and you remember it before 12:00 noon the same day, take the missed dose as soon as possible.
Can you drink caffeine with modafinil?
Notes for Consumers: Limit excessive caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Modafinil. Also avoid medicines containing additional Caffeine whenever possible.
How much modafinil is too much?
Although the maximum recommended daily dose of modafinil is 400 mg, higher doses have been used. There are some patients in whom adequate control of sleepiness may require a slightly higher dose than 400 mg (400 mg in the am and 200 mg in the early afternoon).
How fast does Stevens-Johnson syndrome progress?
Is it OK to take modafinil daily?
The recommended dose for modafinil is 200mg taken once daily . Modafinil has been found to be well-tolerated, with a low incidence of adverse effects and low potential for abuse .