How much hydration do you need for cisplatin?
Patients should be monitored for nephrotoxicity at baseline and prior to each dose of cisplatin, with labs including SCr, BUN, and electrolytes such as potassium and magnesium. To reduce the risk of nephrotoxicity, it is recommended that patients be hydrated with 1 to 2 liters of IV fluids.
How do you prevent cisplatin nephrotoxicity?
The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds.
Why mannitol is given before cisplatin?
Mannitol is an osmotic diuretic that is indicated for the promotion of diuresis; it is a logical choice for reduction of cisplatin-induced nephrotoxicity as it is nontoxic and could reduce the half-life of cisplatin in the kidney.
How do you infuse cisplatin?
Pretreatment hydration with 1 to 2 liters of fluid infused for 8 to 12 hours prior to a cisplatin injection dose is recommended. The drug is then diluted in 2 liters of 5% Dextrose in 1/2 or 1/3 normal saline containing 37.5 g of mannitol, and infused over a 6- to 8-hour period.
What are the guidelines for hydration?
About 15.5 cups (3.7 liters) of fluids a day for men. About 11.5 cups (2.7 liters) of fluids a day for women.
What happens if you don’t drink enough water on chemo?
Cause of dehydration
Cancer and some treatments such as chemotherapy, targeted cancer drugs and immunotherapy can cause the following side effects: vomiting. diarrhoea. sweating because of a fever.
What is the antidote for cisplatin?
No specific antidote for cisplatin exists. Key management principles and strategies to lessen toxicities include renoprotection and enhancing drug elimination with aggressive intravenous hydration with or without the use of an osmotic diuretic, and avoidance of nephrotoxic medications.
How can cisplatin ototoxicity be prevented?
To summarize, the most suitable protocol for treating cisplatin-induced ototoxicity is intratympanic injection to be delivered 1h before each cisplatin injection, due to superior perilymph concentrations within 1 h of administration (Chandrasekhar et al., 2000; Hargunani et al., 2006).
Why is magnesium given with cisplatin?
We hypothesize that supplementation with magnesium before cisplatin infusion protects against renal damage. Renal damage due to cisplatin involves a pathological change in the kidney that is characterized by focal acute tubular necrosis, primarily in the distal convoluted tubule .
Should mannitol be given before or after cisplatin?
I have worked in 2 different infusion clinics, and both administer medications differently. At my current clinic, hydration and mannitol are administered before premedications on a cisplatin regimen.
How fast can you infuse cisplatin?
The cisplatin solution for infusion prepared according to instructions (see section 6.6.) should be administered by intravenous infusion over a period of 6 to 8 hours.
Why is cisplatin stored in saline?
Most studies confirm that cisplatin is chemically stable when diluted in saline in PVC infusions containers stored around ambient temperature over the concentration range of 0.6-1 mg/mL for at least 14 days .
What are the 5 tips for hydration?
5 tips to stay hydrated
- Take it with you. Fill up a reusable water bottle before you leave the house.
- Swap for pop. Sugary drinks contain extra calories.
- Just add flavor. We get it.
- Drink when you move. The American Council of Exercise suggests drinking 17 to 20 ounces of water two to three hours before your workout.
- Eat up.
What is a good baseline for hydration?
You need to consume 80 to 110 milliliters of water for every 100 kilocalories of metabolic rate. For example, if your BMR is 2,000, you should be drinking 1.6 to 2.2 liters of water per day as a baseline.
How much water should a chemo patient drink a day?
Sip all day.
Some health experts suggest at least 8 glasses of liquid a day, even more if you have diarrhea or vomiting. Ask your doctor how much sounds right for you.
How do you keep a chemo patient hydrated?
What the patient can do
- Keep a food and fluid diary.
- Drink fluids.
- Remember that food contains fluid.
- Use lotion often to soften dry skin.
- Try to get rid of the cause of dehydration, such as vomiting, diarrhea, or fever.
- Apply lubricant to lips to avoid painful cracking.
Why is cisplatin so toxic?
Cisplatin causes damage to nuclear and mitochondrial DNA and production of reactive oxygen species (ROS) which lead to activation of both mitochondrial and non-mitochondrial pathways of apoptosis and necrosis. Mitochondrial energetics are also disrupted by cisplatin and may contribute to nephrotoxicity.
What is the most common side effect of cisplatin?
Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity.
Is cisplatin tinnitus reversible?
Cisplatin induced hearing loss is usually bilateral and irreversible, and is particularly serious in the pediatric population (age 6 months and onwards) with cancers like neuroblastomas, CNS malignancies, head and neck cancers, where irradiation of the base of the skull or brain is also performed (Chen et al.
Is cisplatin hearing loss reversible?
“[Cisplatin] is one of the most widely used anticancer drugs on the planet, and it’s saving a lot of lives,” Dr. Cunningham said. But the hearing loss is permanent. “So these patients are surviving and they have this hearing loss for the rest of their lives.
Why does cisplatin cause electrolyte imbalance?
Hypokalemia is a common electrolyte abnormality occurred during cisplatin treatment; it is due to increased renal reabsorption capacity observed in response to decreased intestinal absorption of potassium.
Does cisplatin cause electrolyte imbalance?
Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia, hypocalcemia and hyponatremia.
Why is metoclopramide given before cisplatin?
Metoclopramide inhibits the cytotoxicity of cisplatin and enhances the cytotoxicity of epirubicin.
Is cisplatin stable in water?
Cisplatin is poorly water-soluble, with marginal solubility (approximately 0.15 wt%16). The 50 wt% TMG aq. dissolved 1.7 wt% of cisplatin (Table 1). The diluted TMG solutions (25 and 5 wt%) dissolved less than 1.0 wt% of cisplatin, indicating that high loading of TMG is required to functionalise and dissolve cisplatin.
How do you dissolve cisplatin in water?
You can dissolve cisplatin in deionized water by vortexing it real well, but do not go higher than 2.5 mM, which is the limit. Before use, let the solution into a shaker for 10 min at RT.