Which drug is under BCS II?
Fenofibrate is a low molecular mass (360.4 Da) BCS class II drug that is very lipophilic (log P = 5.24), with an aqueous solubility of <0.1 mg/mL. Fenofibrate is an ester of fenofibric acid. After oral administration in humans, it is completely converted to its active metabolite, fenofibric acid.
What is BCS classification example?
The Biopharmaceutics Classification System (BCS) is a system classifying a drug substance (API) based on its minimum aqueous solubility in the pH range of 1–7.5, dose and human fraction absorbed or intestinal membrane permeability (CDER, 2000).
What are the characteristics of BCS Class 2 drugs?
Class II: low solubility, high permeability: exhibits dissolution rate-limited absorption. Class III: high solubility, low permeability: exhibits permeability-limited absorption. Class IV: low solubility, low permeability: very poor oral bioavailability.
What BCS class is paracetamol?
Initially, paracetamol was classified as a BCS class III compound, however, recently a technical report from the WHO expert committee on specifications for pharmaceutical preparations, classifies it as a BCS class I compound, since it is highly soluble and permeable.
What are BCS 3 drugs?
BCS Class III drug substances are considered to be more susceptible to the effects of excipients. These drugs are not considered highly permeable and may have site-specific absorption, so there are a greater number of mechanisms through which excipients can affect their absorption than for BCS Class I drugs.
What is a Class 3 compound?
Class 3 dangerous goods are flammable liquids with flash points no more than 60 celcius degrees. It covers liquid substances, molten solid substances with a flash point above 60 celcius degrees and liquid desensitized explosives.
What BCS class is aspirin?
A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS).
What BCS class is ibuprofen?
Ibuprofen is a Biopharmaceutics Classification System (BCS) class II drug with low solubility at pH 1.2 and 4.5 and high solubility at pH 6.8. The possibility of extending the “BCS biowaivers” to weak acidic compounds has been suggested.
What BCS class is diclofenac sodium?
BCS class II
Within the biopharmaceutics classification system (BCS), diclofenac potassium and diclofenac sodium are each BCS class II active pharmaceutical ingredients (APIs).
What is the boiling point of ibuprofen?
314.6°F (157°C)Ibuprofen / Boiling point
What BCS class is azithromycin?
AZM is categorized as Biopharmaceutical Classification System (BCS) Class II due to its low solubility and high permeability  .
What is another name for ibuprofen?
Ibuprofen is available under the following different brand names: Advil, Motrin, PediaCare Children’s Pain Reliever/Fever Reducer IB, and PediaCare Infant’s Pain Reliever/Fever Reducer IB.
What is the pH of ibuprofen?
Pharmaceuticals exist in neutral form (hydrophobic) at pH below pKa, but in anionic form (hydrophilic) at pH above pKa (Bui and Choi 2009). Ibuprofen exists in the neutral form at pH 4, the neutral/anionic form at pKa, and the anionic form at pH 7.
What is the significance of BCS classification?
The purpose of BCS is to characterize drugs for which products of those drugs may be eligible for a biowaiver of in vivo bioequivalence studies. The purpose of BDDCS is to predict drug disposition and potential drug-drug interactions in the intestine and the liver, and potentially the kidney and brain.
Can I chew azithromycin?
Swallow the capsules whole – do not break, chew, or crush the capsules. If you take it with food you are less likely to feel sick. Stay upright while swallowing it – ie standing, or sitting – not lying down.
What is another name for aspirin?
Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation.
What is the other name of paracetamol?
acetaminophen, also called paracetamol, drug used in the treatment of mild pain, such as headache and pain in joints and muscles, and to reduce fever.
What is the pH of paracetamol?
The concentration of these conjugates depend on the solution pH and pKa (9.38 for paracetamol, see Table 1) as expressed in the Henderson-Hasselbalch equation.
What is the pKa of paracetamol?
PARACETAMOL (acetaminophen, N-acetyl-p-amino- phenol, 4-hydroxyacetanilide) is a moderately water- and lipid-soluble weak organic acid. It has a pKa value of 9.5 and is therefore largely unionized over the physiological range ofpH.
Why azithromycin is given for 3 days?
Azithromycin is sometimes prescribed long-term to prevent chest infections if you keep getting them. In this case you will usually need to take it 3 times a week, often on a Monday, Wednesday and Friday.
Can I take 2 azithromycin in a day?
Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.
Is paracetamol A aspirin?
Paracetamol is typically used for mild or moderate pain. It may be better than aspirin for headaches, toothache, sprains and stomach ache. Ibuprofen works in a similar way to aspirin. It can be used for back pain, strains and sprains, as well as pain from arthritis.
What is the brand name of aspirin?
Aspirin is available under the following different brand names: Zorprin, Bayer Buffered Aspirin, Durlaza, Asatab, Adprin-B, Alka-Seltzer Extra Strength with Aspirin, Alka-Seltzer with Aspirin, Arthritis Pain Formula, Ascriptin, Ascriptin Maximum Strength, ASA, Bayer Children’s Aspirin, Bayer Women’s Low Dose, Bayer Low …
What are NSAIDs?
Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines that are widely used to relieve pain, reduce inflammation, and bring down a high temperature. They’re often used to relieve symptoms of headaches, painful periods, sprains and strains, colds and flu, arthritis, and other causes of long-term pain.
What is the pH level of aspirin?
Among the patients who had oral pH below 6.5, 70.9% (168 out of 237) took aspirin and 29.1% (69 out of 237) did not take aspirin (Pearson’s Chi square test, χ2 = 7.8, degree of freedom = 1, P < 0.01).
|Number (%) or median (IQR)|
|HTN along||126 (34.2%)|
|IHD along||73 (19.8%)|
|CVA along||145 (39.4%)|